Zenakine™ is a biotechnology-derived neuroactive cosmetic ingredient designed to help skin and mind recover from the visible and invisible effects of stress. Its INCI name is Lactobacillus Ferment Lysate (and) Glycerin (and) Pentylene Glycol (and) Propanediol (and) Xanthan Gum. Developed by Croda, Zenakine™ is sourced through microbial fermentation and positioned as a skin conditioning agent with unique benefits linked to biological rhythm alignment.

Unlike conventional actives that focus solely on topical repair, Zenakine™ works in sync with the skin’s circadian and neurocutaneous pathways. It enhances melatonin production, supporting better sleep quality and duration – and it is the first cosmetic ingredient with clinical instrumental evidence of sleep improvement. By influencing neuro-skin connections, it not only helps the skin regenerate overnight but also contributes to elevated positive emotions and overall wellbeing.

Functionally, Zenakine™ delivers anti-aging, calming, soothing, and revitalizing effects. It helps reduce redness, improves resilience against environmental stressors, and supports physiological balance. These combined actions make it highly suitable for formulations targeting eye contour care, facial and neck care, scalp treatments, and stress-related skin concerns.

From a sustainability and compliance perspective, Zenakine™ aligns with modern formulation needs. It is COSMOS Natural approved, RSPO-certified, Halal, vegan, and 100% natural origin content (ISO 16128). It is also biodegradable (OECD 301B) and free from commonly restricted additives including EO/PO, EDTA, BHT/BHA, parabens, and PEGs.

In summary, Zenakine™ represents a new category of neurocosmetic ingredient: one that merges biotechnology, stress biology, and circadian rhythm science. By supporting both emotional balance and visible skin vitality, it reflects a holistic approach to cosmetic innovation where wellbeing and appearance are inseparably linked.