Grapefruit seed extract (GSE) is a natural substance derived from the seeds, pulp, and white membranes of grapefruit. Known for its antimicrobial, antioxidant, and preservative properties, it is commonly used in skincare, dietary supplements, and natural cleaning products. Rich in bioflavonoids and polyphenols, GSE helps protect the skin from oxidative stress, supports wound healing, and has been studied for its potential antibacterial and antifungal benefits. In skincare, it is often included in formulations to help soothe irritation, combat acne-causing bacteria, and extend the shelf life of products. While generally considered safe in diluted concentrations, concerns have been raised about some commercial extracts containing synthetic preservatives. For this reason, high-quality, pure sources of grapefruit seed extract are preferred in natural formulations.